Incazelo

I-Rosuvastatin Calcium (BANM, JAN, USAN) yaziwa njenge-Rosuvastatin e-US.kanye ne-HMG-CoA reductase inhibitor eqhudelanayo ene-IC50 ye-11 nM[1].I-Rosuvastatin Calcium ivimba ngokunamandla isakhi sofuzo esihlobene ne-ether-a-go-go (i-hERG) yamanje ene-IC50 ye-195 nM, ukubambezeleka kokuphindaphindeka kwenhliziyo, futhi ngaleyo ndlela ubude besikhathi obunamandla besenzo (APD) nokulungisa izikhawu ze-QT (QTc)[2].I-Rosuvastatin Calcium yehlisa ukuvezwa kwe-hERG evuthiwe kanye nokusebenzisana kwe-heat shock protein 70 (Hsp70) nephrotheni ye-hERG.I-Rosuvastatin Calcium iphumelela kakhulu ekwehliseni i-low-density lipoprotein (LDL) cholesterol, triglycerides, kanye namazinga amaprotheni asebenzayo e-C[3].

Ulwazi olwengeziwe mayelana nezivumelwano zokuqamba izidakamizwa: Amagama Angewona Abanikazi Bamazwe Ngamazwe.

Isaziso Esibalulekile: Isizindalwazi samazwe ngamazwe se-Drugs.com siphuma ku-BETA.Lokhu kusho ukuthi isathuthukiswa futhi ingase iqukethe izinto ezingalungile.Akuhloselwe ukuthatha indawo yobungcweti nokwahlulela kukadokotela wakho, usokhemisi noma omunye uchwepheshe wezokunakekelwa kwempilo.Akufanele kuthathwe njengokusho ukuthi ukusetshenziswa kwanoma yimuphi umuthi kunoma yiliphi izwe kuphephile, kukufanele noma kuyasebenza kuwe.Xhumana nochwepheshe bakho bezempilo ngaphambi kokuthatha noma yimuphi umuthi.

E-US, i-rosuvastatin (i-rosuvastatin systemic) iyilungu lesigaba sezidakamizwa futhi isetshenziselwa ukwelapha i-Atherosclerosis, I-Cholesterol Ephezulu, I-Cholesterol Ephezulu - I-Familial Heterozygous, I-Cholesterol Ephezulu - I-Homozygous Yomndeni, I-Hyperlipoproteinemia, I-Hyperlipoproteinemia Uhlobo IIa - I-LDL Ephakeme, I-Hyperlipoproteinemia I-IIb - I-VLDL ephezulu ye-LDL, i-Hyperlipoproteinemia Uhlobo lwe-III - I-beta-VLDL IDL ephakeme, i-Hyperlipoproteinemia Uhlobo lwe-IV - I-VLDL Ephakeme, i-Hypertriglyceridemia kanye Nokuvimbela Izifo Zenhliziyo.

Ingemuva

I-inhibitor ekhethiwe, encintisanayo ye-HMG-CoA reductase, ephinde ibe ne-antilipemic.

Isitoreji

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