I-Rosuvastatin Calcium
| 瑞舒伐他汀钙 | I-Rosuvastatin Calcium | 147098-20-2 | Endlini/CEP |
| I-RSM(Crystal) | 147118-40-9 | Endlini | |
| I-RSM(Crude) | 147118-40-9 | Endlini | |
| I-RSP | - | Endlini | |
| RS-8 | 147118-36-3 | Endlini | |
| RS-8-1 | 147118-37-4 | Endlini | |
| I-TP-8 | 131466-61-0 | Endlini | |
| I-TP-11 | 147118-35-2 | Endlini | |
| I-TP-13 | 147118-39-6 | Endlini | |
| RS-10 | 289042-12-2 | Endlini | |
| RS-11 | 355806-00-7 | Endlini |
Incazelo
I-Rosuvastatin Calcium (BANM, JAN, USAN) yaziwa ngokuthi i-Rosuvastatin e-US. kanye ne-HMG-CoA reductase inhibitor eqhudelanayo ene-IC50 ye-11 nM[1]. I-Rosuvastatin Calcium ivimba ngokunamandla isakhi sofuzo esihlobene ne-ether-a-go-go (i-hERG) yamanje ene-IC50 ye-195 nM, ukubambezeleka kwe-cardiac repolarization, bese ngaleyo ndlela kuthathe isikhathi eside esingase sibe khona (APDs) kanye nezikhawu ezilungisiwe ze-QT interval (QTc)[2]. I-Rosuvastatin Calcium yehlisa ukuvezwa kwe-hERG evuthiwe kanye nokusebenzisana kwe-heat shock protein 70 (Hsp70) nephrotheni ye-hERG. I-Rosuvastatin Calcium iphumelela kakhulu ekwehliseni i-low-density lipoprotein (LDL) cholesterol, triglycerides, kanye namazinga amaprotheni asebenzayo e-C[3].
Ulwazi olwengeziwe mayelana nezivumelwano zokuqamba izidakamizwa: Amagama Angewona Abanikazi Bamazwe Ngamazwe.
Isaziso Esibalulekile: Isizindalwazi samazwe ngamazwe se-Drugs.com sikhishwe nge-BETA. Lokhu kusho ukuthi isathuthukiswa futhi ingase iqukethe izinto ezingalungile. Akuhloselwe ukuthatha indawo yobungcweti nokwahlulela kukadokotela wakho, usokhemisi noma omunye uchwepheshe wezokunakekelwa kwempilo. Akufanele kuthathwe njengokusho ukuthi ukusetshenziswa kwanoma yimuphi umuthi kunoma yiliphi izwe kuphephile, kukufanele noma kuyasebenza kuwe. Xhumana nochwepheshe bakho bezempilo ngaphambi kokuthatha noma yimuphi umuthi.
E-US, i-Rosuvastatin (i-rosuvastatin systemic) iyilungu lesigaba sezidakamizwa futhi isetshenziselwa ukwelapha i-Atherosclerosis, I-Cholesterol Ephezulu, I-Cholesterol Ephezulu - I-Familial Heterozygous, I-Cholesterol Ephezulu - I-Homozygous Yomndeni, I-Hyperlipoproteinemia, I-Hyperlipoproteinemia Uhlobo IIa - I-LDL Ephakanyisiwe, I-Hyperlipopro I-IIb - i-LDL ephakanyisiwe ye-VLDL, I-Hyperlipoproteinemia Uhlobo lwe-III - I-beta-VLDL ephezulu ye-IDL, i-Hyperlipoproteinemia Uhlobo IV - I-VLDL Ephakanyisiwe, i-Hypertriglyceridemia kanye Nokuvimbela Izifo Zenhliziyo.
Ingemuva
I-inhibitor ekhethiwe, encintisanayo ye-HMG-CoA reductase, ephinde ibe ne-antilipemic.
Isitoreji
| Impushana | -20°C | 3 iminyaka |
| 4°C | iminyaka engu-2 | |
| Ku-solvent | -80°C | 6 izinyanga |
| -20°C | Inyanga engu-1 |
Isakhiwo samakhemikhali
Isiphakamiso18Amaphrojekthi Wokuhlola Ukuvumelana Kwekhwalithi asegunyaziwe4, futhi6amaphrojekthi angaphansi kokugunyazwa.
Uhlelo lokuphatha ikhwalithi yamazwe ngamazwe oluthuthukile lwenze isisekelo esiqinile sokuthengisa.
Ukugadwa kwekhwalithi kusebenza kuwo wonke umjikelezo wempilo womkhiqizo ukuze kuqinisekiswe ikhwalithi nomphumela wokwelapha.
Ithimba Lezindaba Zokulawula Ochwepheshe lisekela izimfuno zekhwalithi ngesikhathi sokufaka isicelo nokubhaliswa.
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