Incazelo

I-Pitavastatin Calcium (NK-104 hemicalcium) iyi-hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor enamandla. I-Pitavastatin Calcium (NK-104 hemicalcium) ivimbela ukwakheka kwe-cholesterol ku-acetic acid nge-IC50 ka-5.8 nM kumaseli e-HepG2. I-Pitavastatin Calcium iyi-hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer esebenzayo. Umsebenzi wokulwa nomdlavuza.

Ingemuva

I-Pitavastatin Calcium iyi-inhibitor encintisanayo ye-enzyme HMGCR (HMG-CoA reductase) iphumela ekuncipheni kwe-LDL cholesterol synthesis. Olunye ucwaningo lubonisa ukuthi i-pitavastatin ingacindezela ukukhiqizwa komoyampilo kumaseli e-endothelial ngokuvimbela i-NADPH oxidase. Ngaphezu kwalokho, i-pitavastatin yehlisa ukuvezwa kwe-eNOS mRNA ngenkathi ikhulisa impendulo encike ku-NO egqugquzelwa i-acetylcholine ne-calcium ionophore, A23187. Ngaphezu kwalokho, i-pitavastatin ivimbela ukulawulwa kwe-conductance calcium-activated potassium channels ngokwehlisa amazinga e-cholesterol kumaseli.

Isitoreji

4°C, vikela ekukhanyeni

*Ku-solvent : -80°C, izinyanga ezingu-6; -20°C, inyanga engu-1 (vikela ekukhanyeni)

Isakhiwo samakhemikhali

Idatha Yebhayoloji Ehlobene