I-Captopril
Incazelo
I-Captopril (SQ-14534) inamandla, inhibitor yokuncintisana ye-angiotensin-converting enzyme (ACE).
Ku-Vitro
I-Captopril (SQ-14534) ikhonjiswe ukuthi inezinzuzo ezifanayo zokugula nokufa nalezo zama-diuretics nama-beta-blockers ezigulini ezinomfutho wegazi ophakeme.I-Captopril (SQ-14534) ikhonjiswe ukuthi ibambezela ukuqhubeka kwe-nephropathy yesifo sikashukela, futhi i-enalapril ne-lisinopril ivimbela ukukhula kwe-nephropathy ezigulini ze-normoalbuminuric ezinesifo sikashukela[1].Isilinganiso esilinganayo se-cis kanye ne-trans States ye-Captopril (SQ-14534) sikhona kusixazululo nokuthi i-enzyme ikhetha kuphela isimo esishintshayo se-inhibitor esiveza ukuhambisana kwezakhiwo kanye ne-stereoelectronic ne-groove yayo ebopha i-substrate[2].
I-MCE ayizange iqinisekise ngokuzimela ukunemba kwalezi zindlela.Ezethenjwa kuphela.
Ukuhlolwa Komtholampilo
| Inombolo ye-NCT | Umxhasi | Isimo | Usuku okuqalwa ngalo | Isigaba |
| I-NCT03179163 | I-Penn State University|National Heart, Lung, and Blood Institute (NHLBI) | I-Hypertension, ibalulekile | Julayi 20, 2016 | Isigaba 1|Isigaba 2 |
| I-NCT03660293 | Inyuvesi yaseTanta | Isifo sikashukela i-mellitus, uhlobo 1 | Ephreli 1, 2017 | Akufaneleki |
| I-NCT03147092 | I-Centro Neurológico de Pesquisa e Reabiitação, Brazil | Umfutho Wegazi | Umfutho Wegazi | Februwari 1, 2018 | Isigaba sokuqala 1 |
| I-NCT00252317 | I-Rigshospitalet, Denmark | I-Aortic stenosis | Novemba 2005 | Isigaba 4 |
| I-NCT02217852 | Isibhedlela sase-West China | Umfutho wegazi ophezulu | Agasti 2014 | Isigaba 4 |
| I-NCT01626469 | Brigham and Women's Hospital | Thayipha 2 Isifo sikashukela i-mellitus | Meyi 2012 | Isigaba 1|Isigaba 2 |
| I-NCT00391846 | AstraZeneca | Ukwehluleka Kwenhliziyo|Ukungasebenzi Kwe-Ventricular, Kwesobunxele | Okthoba 2006 | Isigaba 4 |
| I-NCT00240656 | I-Hebei Medical University | I-Hypertension, i-Pulmonary | Okthoba 2005 | Isigaba 1 |
| I-NCT00086723 | Inyuvesi yaseNorthwestern|National Cancer Institute (NCI) | Isimila Esiqinile Sabantu Abadala Esingashiwongo, I-Protocol Specific | Julayi 2003 | Isigaba 1|Isigaba 2 |
| I-NCT00663949 | I-Shiraz University of Medical Sciences | Isifo sikashukela i-Nephropathy | February 2006 | Isigaba 2|Isigaba 3 |
| I-NCT01437371 | Isibhedlela saseNyuvesi, eClermont-Ferrand|Servier|LivaNova | Ukuhluleka Kwenhliziyo | Agasti 2011 | Isigaba 3 |
| I-NCT04288700 | Inyuvesi yase-Ain Shams | I-Hemangioma yezingane | Okthoba 1, 2019 | Isigaba 4 |
| I-NCT00223717 | I-Vanderbilt University|Vanderbilt University Medical Center | Umfutho wegazi ophezulu | Januwari 2001 | Isigaba 1 |
| I-NCT02770378 | Inyuvesi yase-Ulm|Izindlela Zokwelapha Zomdlavuza Ezithembekile|Isikhwama Somdlavuza, eBelgium | I-Glioblastoma | Novemba 2016 | Isigaba 1|Isigaba 2 |
| I-NCT01761916 | Instituto Materno Infantil Prof. Fernando Figueira | I-Preeclampsia | Januwari 2013 | Isigaba 4 |
| I-NCT01545479 | I-Instituto de Cardiologia do Rio Grande do Sul | Isifo sezinso | Januwari 2010 | Isigaba 4 |
| I-NCT00935805 | Isibhedlela de Clinicas de Porto Alegre|Conselho Nacional de Desenvolvimento Científico e Tecnológico|Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil | Isifo sikashukela i-mellitus | I-Arterial Hypertension | Julayi 2006 |
|
| I-NCT00742040 | Isibhedlela Sezingane Ezigulayo | Isifo senhliziyo | Agasti 2008 | Isigaba 2 |
| I-NCT03613506 | Inyuvesi yaseWuhan | I-Radiotherapy Side Effect|Ukuthatha i-Captopril | Okthoba 25, 2018 | Isigaba 2 |
| I-NCT00004230 | Inyuvesi yaseNorthwestern|National Cancer Institute (NCI) | Umdlavuza | Okthoba 1999 | Isigaba 3 |
| I-NCT00660309 | Novartis | Thayipha 2 Isifo sikashukela i-mellitus | Ephreli 2008 | Isigaba 4 |
| I-NCT00292162 | I-NHS Greater Glasgow kanye noClyde | Ukwehluleka Kwenhliziyo Okungapheli|I-Atrial Fibrillation | Januwari 2007 | Akufaneleki |
| I-NCT01271478 | Coordinación de Investigación en Salud, Mexico | Ukuvuvukala|Isifo Sokuphela Kwezinso | Agasti 2009 | Isigaba 4 |
| I-NCT04193137 | I-Chongqing Medical University | I-Aldosteronism eyinhloko | Novemba 30, 2019 |
|
| I-NCT00155064 | I-National Taiwan University Hospital | I-Hyperaldosteronism | Julayi 2002 | Isigaba 4 |
| I-NCT01292694 | I-Vanderbilt University|Vanderbilt University Medical Center | I-Hypertension|Ukwehluleka Okuzenzakalelayo Okumsulwa|I-Multiple System Atrophy | Mashi 2011 | Isigaba 1 |
| I-NCT00917345 | Isibhedlela Sikazwelonke saseTaiwan University|Novartis | I-Aldosteronism eyinhloko | Januwari 2008 |
|
| I-NCT00077064 | I-Radiation Therapy Oncology Group|National Cancer Institute (NCI)|NRG Oncology | Umdlavuza wamaphaphu|Izinkinga zamaphaphu|I-Radiation Fibrosis | Juni 2003 | Isigaba 2 |
Isitoreji
| Impushana | -20°C | 3 iminyaka |
| 4°C | iminyaka engu-2 | |
| Ku-solvent | -80°C | 6 izinyanga |
| -20°C | Inyanga engu-1 |
Isakhiwo samakhemikhali
Isiphakamiso18Amaphrojekthi Wokuhlola Ukuvumelana Kwekhwalithi asegunyaziwe4, futhi6amaphrojekthi angaphansi kokugunyazwa.
Uhlelo lokuphatha ikhwalithi yamazwe ngamazwe oluthuthukile lwenze isisekelo esiqinile sokuthengisa.
Ukugadwa kwekhwalithi kusebenza kuwo wonke umjikelezo wempilo womkhiqizo ukuze kuqinisekiswe ikhwalithi nomphumela wokwelapha.
Ithimba Lezindaba Zokulawula Ochwepheshe lisekela izimfuno zekhwalithi ngesikhathi sokufaka isicelo nokubhaliswa.
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