China Bictegravir 1611493-60-7 abakhiqizi nabaphakeli |I-CPF

I-Bictegravir 1611493-60-7

Incazelo emfushane:

Igama le-API	Inkomba	Umsunguli	Idethi yokuphelelwa yisikhathi kwelungelo lobunikazi(e-US)
I-Bictegravir 1611493-60-7	Ukutheleleka nge-HIV-1	Isayensi YaseGileyadi	Disemba 19, 2033

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

IMINININGWANE YOMKHIQIZO

Incazelo

I-Bictegravir iyinoveli, inhibitor enamandla ye-HIV-1 integrase ene-IC50 engu-7.5 nM.

Ku-Vitro

I-Bictegravir (BIC) ivimbela umsebenzi wokudlulisa i-strand nge-IC50 ye-7.5± 0.3 nM.Ngokuphathelene nokuvinjwa kwayo komsebenzi wokudlulisa i-strand, i-Bictegravir iyi-inhibitor ebuthakathaka kakhudlwana yama-3.'-ukucubungula umsebenzi we-HIV-1 IN, nge-IC50 yama-241±51 nM.I-Bictegravir ithuthukisa ukunqwabelana kwendilinga engu-2-LTR ~ 5 ngokuphindwe ka-5 ngokuhlobene nokulawula okwenziwe mbumbulu futhi yehlisa inani lemikhiqizo eyiqiniso yokuhlanganisa kumaseli anegciwane ngokuphindwe kayikhulu.I-Bictegravir ivimbela ngokunamandla ukuphindaphinda kwe-HIV-1 kuwo womabili amaseli e-MT-2 kanye ne-MT-4 anama-EC50s we-1.5 kanye no-2.4 nM, ngokulandelana.I-Bictegravir ibonisa imiphumela enamandla yokulwa namagciwane kuwo womabili ama-lymphocyte e-CD4+ T ayinhloko kanye nama-macrophages atholakala ku-monocyte, nama-EC50s angu-1.5±0.3 nM kanye no-6.6±4.1 nM, ngokulandelanayo, aqathaniswa namanani atholwe emigqeni ye-T-cell[1].

I-MCE ayizange iqinisekise ngokuzimela ukunemba kwalezi zindlela.Ezethenjwa kuphela.

Inombolo ye-NCT	Umxhasi	Isimo	Usuku okuqalwa ngalo	Isigaba
I-NCT03998176	Inyuvesi yaseNebraska\|Gilead Sciences	I-HIV-1-ukutheleleka	Okthoba 9, 2019	Isigaba 4
I-NCT03789968	Thomas Jefferson University\|University of Maryland, College Park\|Indiana University Health\|The Brooklyn Hospital Center\|University of Illinois eChicago\|Nova Southeastern University\|University of California, San Francisco	I-HIV+AIDS	Septhemba 1, 2019
I-NCT04249037	Inyuvesi yaseColorado, eDenver\|Gilead Sciences	I-HIV+AIDS	Mashi 1, 2020	Akufaneleki
I-NCT04132674	Isikhungo Sezifo Ezithathelwanayo saseVancouver	I-Human Immunodeficiency Virus I Infection\|Ukusetshenziswa Kwezidakamizwa	Novemba 26, 2018	Isigaba 4
I-NCT04054089	Cristina Mussini\|University of Modena kanye noReggio Emilia	Ukutheleleka nge-HIV	Septhemba 2019	Isigaba 4
I-NCT04155554	Azienda Ospedaliera Universitaria Senese\|Catholic University of the Sacred Heart\|Ospedale Policlinico San Martino\|Azienda Ospedaliera San Paolo\|Ospedale Amedeo di Savoia	I-HIV-1-ukutheleleka	Januwari 29, 2020	Isigaba 3
I-NCT02275065	Isayensi YaseGileyadi	I-HIV-1 Ukutheleleka	Okthoba 2014	Isigaba 1
I-NCT03711253	Inyuvesi yaseSouthern California	Ukutheleleka nge-HIV Acute	Okthoba 14, 2019	Isigaba 4
I-NCT02400307	Isayensi YaseGileyadi	I-HIV	Ephreli 17, 2015	Isigaba 1
I-NCT03499483	I-Fenway Community Health	Ukuvimbela I-HIV	Januwari 24, 2019	Isigaba 4
I-NCT03502005	Midland Research Group, Inc.\|Gilead Sciences	I-Human Immunodeficiency Virus	Mashi 1, 2018	Isigaba 4