Incazelo

I-Sugammadex sodium iyi-synthetic γ-cyclodextrin derivative, futhi isebenza njenge-ejenti entsha yokuhlehla ye-neuromuscular block.

Igama elijwayelekile: sugammadex (soo GAM ma dex)
Igama lebrand: Bridion

I-Sugammadex ibuyisela emuva imiphumela yemithi ethile enikezwa ngesikhathi sokuhlinzwa ukuze uphumule imisipha yakho.

I-Sugammadex isetshenziswa ekupheleni kokuhlinzwa, ukusiza ukubuyisela ukusebenza kwemisipha okuye kwavinjelwa ngesikhathi sokuhlinzwa eminye imithi.

I-Sugammadex ingase isetshenziselwe izinjongo ezingabaliwe kulo mhlahlandlela wemithi.

Isetshenziselwa ukubuyisela emuva imiphumela yezinye izidakamizwa.

Ku-Vivo

Umjovo we-sugammadex awunayo imiphumela ebalulekile kumfutho wegazi noma ukushaya kwenhliziyo.Ngemuva kokujova umthamo ophezulu we-rocuronium, ukubuyiselwa kwe-90% kwesilinganiso sesitimela-sesine kuthatha i-28 min (SD 7 min) ngemva kwe-saline, i-26 min (SD 9.5 min) ngemva kwe-1 mg / kg sugammadex, ne-8 min (SD 3.6 min) ngemva kwe-2.5 mg/kg sugammadex[1].I-Sugammadex ibangela ukuguqulwa okusheshayo nokuphelele kwe-rocuronium-induced neuromuscular block.Isikhathi sokutakula sokuqeqesha okune isilinganiso=0.9 ngemva kokululama okuzenzakalelayo yimizuzu engu-14.4 (SD=3.4 min; n=14).Lokhu kuncishiswe kakhulu kumaminithi angu-3.7 (SD=3.3 min; n=4) nge-sugammadex 0.5 mg/kg kanye namaminithi angu-1.9 (SD=1.0 min; n=4) nge-sugammadex 1.0 mg/kg[2].Isilinganiso sempilo yesigamu se-sugammadex ku-Rhesus monkey singama-30 (SEM=4.9) amaminithi[3].

Isitoreji

Isakhiwo samakhemikhali