Incazelo

I-Sugammadex sodium iyi-synthetic γ-cyclodextrin derivative, futhi isebenza njenge-ejenti entsha yokuhlehla ye-neuromuscular block.

Igama elijwayelekile: sugammadex (soo GAM ma dex)
Igama lebrand: Bridion

I-Sugammadex ihlehlisa imiphumela yemithi ethile enikezwa ngesikhathi sokuhlinzwa ukuze uphumule imisipha yakho.

I-Sugammadex isetshenziswa ekupheleni kokuhlinzwa, ukusiza ukubuyisela ukusebenza kwemisipha okuye kwavinjelwa ngesikhathi sokuhlinzwa eminye imithi.

I-Sugammadex ingase isetshenziselwe izinjongo ezingabaliwe kulo mhlahlandlela wemithi.

Isetshenziselwa ukubuyisela emuva imiphumela yezinye izidakamizwa.

Ku-Vivo

Umjovo we-sugammadex awunayo imiphumela ebalulekile kumfutho wegazi noma ukushaya kwenhliziyo. Ngemuva kokujova umthamo ophezulu we-rocuronium, ukubuyiswa kwe-90% kwesilinganiso sesitimela-sesine kuthatha i-28 min (SD 7 min) ngemva kwe-saline, i-26 min (SD 9.5 min) ngemva kwe-1 mg / kg sugammadex, ne-8 min (SD) 3.6 min) ngemva kwe-2.5 mg/kg sugammadex[1]. I-Sugammadex ibangela ukuguqulwa okusheshayo nokuphelele kwe-rocuronium-induced neuromuscular block. Isikhathi sokutakula sokuqeqeshwa kwesilinganiso esine=0.9 ngemva kokululama okuzenzakalelayo siyimizuzu engu-14.4 (SD=3.4 min; n=14). Lokhu kuncishiswe kakhulu kumaminithi angu-3.7 (SD=3.3 min; n=4) nge-sugammadex 0.5 mg/kg futhi kuya ku-1.9 min (SD=1.0 min; n=4) nge-sugammadex 1.0 mg/kg[2]. Isilinganiso sempilo yesigamu se-sugammadex ku-Rhesus monkey singama-30 (SEM=4.9) amaminithi[3].

Isitoreji

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