I-Pomalidomide, phambilini eyayaziwa ngokuthi i-CC-4047 noma i-actimid, iyingqamuzana enamandla yokuzivikela komzimba ebonisa umsebenzi we-antineoplastic ekwelapheni izifo eziphathelene ne-hematological, ikakhulukazi i-multiple myeloma (MM) ephinde yabuyela emuva kanye ne-refractory. Njengokuphuma ku-thalidomide, i-pomalidomide inokwakheka kwamakhemikhali okufanayo njenge-thalidomide ngaphandle kokwengezwa kwamaqembu e-oxo amabili eringini ye-phthaloyl kanye neqembu le-amino endaweni yesine. Ngokuvamile, njenge-molecule ye-immunomodulatory, i-pomalidomide ibonisa umsebenzi we-antitumor ngokusebenzisa indlela yokuvimbela i-tumor microenvironment ngokushintshanisa ama-cytokines asekela isimila (TNF-α, IL-6, IL-8 kanye ne-VEGF), eqondisa ngokuqondile imisebenzi ebalulekile yesimila. amaseli, nosekelo olubandakanyayo oluvela kumaseli angawona amasosha omzimba.

I-Pomalidomide isetshenziselwa ukwelapha i-myeloma eminingi (umdlavuza obangelwa isifo segazi esiqhubekayo). I-pomalidomide ivamise ukunikezwa ngemva kokuthi kuzanywe okungenani eminye imithi emibili ngaphandle kwempumelelo.

I-pomalidomide iphinde isetshenziselwe ukwelapha i-Kaposi sarcoma ehlobene nengculazi lapho eminye imithi ingasebenzi noma iyekile ukusebenza. I-pomalidomide ingasetshenziswa futhi ukwelapha i-Kaposi Sarcoma kubantu abadalaI-HIV-negative.

I-pomalidomide itholakala kuphela ekhemisi eliqinisekisiwe ngaphansi kohlelo olukhethekile. Kufanele ubhalise ohlelweni futhi uvume ukusebenzisaukulawula inzaloizinyathelo njengoba kudingeka.

I-pomalidomide ingase isetshenziselwe izinjongo ezingabaliwe kulo mhlahlandlela wemithi.

I-pomalidomide ingabangela ukukhubazeka okunzima, okusongela ukuphila noma ukufa kwengane uma umama noma ubaba ethatha i-pomalidomide ngesikhathi sokukhulelwa noma ngesikhathi sokukhulelwa. Ngisho nomthamo owodwa we-pomalidomide ungabangela ukukhubazeka okukhulu ezingalweni nemilenze yomntwana, amathambo, izindlebe, amehlo, ubuso nenhliziyo. Ungalokothi usebenzise i-pomalidomide uma ukhulelwe. Tshela udokotela wakho ngokushesha uma isikhathi sakho sekwephuzile ngenkathi uthatha i-pomalidomide.