I-Ruxolitinibwuhlobo lomuthi ohlosiwe womdlavuza.Isetshenziselwa kakhulu ukuvimbela ukwenziwa kusebenze kwendlela yokusayina ye-JAK-STAT futhi yehlise isignali ecindezela ukuthuthukiswa okungavamile, ngaleyo ndlela kuzuze umphumela wokwelapha.Isebenza ngokuvimbela umzimba wakho ekukhiqizeni izinto ezibizwa ngokuthi izici zokukhula.Akwazi nje ukwelapha isifo esisodwa endaweni yokwelapha i-hematology, kodwa futhi yelapha ama-myeloproliferative neoplasms akudala (abuye abizwe nge-BCR-ABL1-negative MPNs), i-JAK exon 12 mutations, i-CALR, ne-APL, njll.
Ithini idosi yokuqala enconyiwe?
Kungabangela imiphumela engemihle kuhlanganise ne-myelosuppression futhi, okuholela ekubonakalisweni komtholampilo okungase kube yingozi kakhulu njenge-neutropenia, i-thrombocytopenia, i-leukemia kanye ne-anemia.Ngakho-ke ukunakekelwa okukhethekile kufanele kuthathwe ekunqumeni imithamo yokuqala lapho kunqunywe iziguli.Umthamo wokuqala onconyiwe we-Ruxolitinib uncike kakhulu ekubalweni kwe-PLT yesiguli.Ezigulini ezinesibalo seplatelet esingaphezu kwama-200, umthamo wokuqala ngu-20 mg kabili ngosuku;kulabo abanesibalo seplatelet ebangeni elisukela ku-100 kuye ku-200, umthamo wokuqala ngu-15 mg kabili ngosuku;Ezigulini ezine-platelet count ephakathi kuka-50 no-100, umthamo wokuqala wokuqala ngu-5 mg kabili ngosuku.
Izinyathelo zokuqapha ngaphambi kokuthathaI-Ruxolitinib
Okokuqala, khetha udokotela onolwazi olucebile ekwelapheni nge-Ruxolitinib.Tshela udokotela wakho uma i-allergies kuwo, noma uma unokuthile okunye okungakuphathi kahle.Ingase iqukethe izithako ezingasebenzi, ezingabangela ukungezwani komzimba noma ezinye izinkinga.
Okwesibili, hlola njalo ukubalwa kwakho kwe-PLT.Isibalo segazi esiphelele kanye nokubalwa kweplatelet kufanele kurekhodwe njalo emavikini angu-2-4 kusukela kuthathwe i-Ruxolitinib kuze kube yilapho imithamo isizinzile, bese ihlolwa uma izinkomba zomtholampilo zidinga lokho.
Okwesithathu, lungisa imithamo ngendlela efanele.Umthamo wokuqala awuvamile ukulungiswa uma uthatha i-Ruxolitinib kodwa unenani eliphansi leplatelet ekuqaleni.Uma isibalo sakho se-PLT sikhuphuka njengoba ukwelashwa okuhlosiwe okuhlosiwe kuqhubeka, ungakwazi kancane kancane ukwandisa umthamo wakho ngokulandela imiyalelo kadokotela wakho ngokucophelela.
Okokugcina, tshela udokotela wakho umlando wakho wezokwelapha, ikakhulukazi izinkinga ze-myeloproliferative ezifana nesifo sezinso, isifo sesibindi, nomdlavuza wesikhumba.Ezinye izidakamizwa noma ukwelashwa kufanele kuthathe indawo ye-Ruxolitinib uma ungafaneleki kuyo.
Isikhathi sokuthumela: Apr-25-2022