I-Ruxolitinibwuhlobo lomuthi ohlosiwe womdlavuza. Isetshenziselwa kakhulu ukuvimbela ukwenziwa kusebenze kwendlela yokusayina ye-JAK-STAT nokwehlisa isignali ecindezela ukuthuthukiswa okungavamile, ngaleyo ndlela kuzuze umphumela wokwelapha. Isebenza ngokuvimbela umzimba wakho ekukhiqizeni izinto ezibizwa ngokuthi izici zokukhula. Akwazi nje ukwelapha isifo esisodwa endaweni yokwelapha i-hematology, kodwa futhi yelapha ama-myeloproliferative neoplasms (abizwa nangokuthi ama-BCR-ABL1-negative MPNs), i-JAK exon 12 mutations, i-CALR, ne-APL, njll.
Ithini idosi yokuqala enconyiwe?
Kungabangela imiphumela engemihle kuhlanganise ne-myelosuppression futhi, okuholela ekubonakalisweni komtholampilo okungase kube yingozi kakhulu njenge-neutropenia, i-thrombocytopenia, i-leukemia kanye ne-anemia. Ngakho-ke ukunakekelwa okukhethekile kufanele kuthathwe ekunqumeni imithamo yokuqala lapho kunqunyelwa iziguli. Umthamo wokuqala onconyiwe we-Ruxolitinib uncike kakhulu ekubalweni kwe-PLT yesiguli. Ezigulini ezinesibalo seplatelet esingaphezu kwama-200, umthamo wokuqala ngu-20 mg kabili ngosuku; kulabo abanesibalo seplatelet ebangeni elisukela ku-100 kuye ku-200, umthamo wokuqala ngu-15 mg kabili ngosuku; Ezigulini ezine-platelet count ephakathi kuka-50 no-100, umthamo wokuqala wokuqala ngu-5 mg kabili ngosuku.
Izinyathelo zokuqapha ngaphambi kokuthathaI-Ruxolitinib
Okokuqala, khetha udokotela onolwazi olucebile ekwelapheni nge-Ruxolitinib. Tshela udokotela wakho uma uguliswa yiwo, noma uma unokuthile okungezwani nakho. Ingase iqukethe izithako ezingasebenzi, ezingabangela ukungezwani komzimba noma ezinye izinkinga.
Okwesibili, hlola njalo ukubalwa kwakho kwe-PLT. Isibalo segazi esiphelele kanye nokubalwa kweplatelet kufanele kurekhodwe njalo emavikini angu-2-4 kusukela kuthathwe i-Ruxolitinib kuze kube yilapho imithamo isizinzile, bese ihlolwa uma izinkomba zomtholampilo zidinga lokho.
Okwesithathu, lungisa imithamo ngendlela efanele. Umthamo wokuqala awuvamile ukulungiswa uma uthatha i-Ruxolitinib kodwa unenani eliphansi leplatelet ekuqaleni. Uma isibalo sakho se-PLT sikhuphuka njengoba ukwelashwa okuhlosiwe okuhlosiwe kuqhubeka, ungakwazi kancane kancane ukwandisa umthamo wakho ngokulandela imiyalelo kadokotela wakho ngokucophelela.
Okokugcina, tshela udokotela wakho umlando wakho wezokwelapha, ikakhulukazi izinkinga ze-myeloproliferative ezifana nesifo sezinso, isifo sesibindi, nomdlavuza wesikhumba. Ezinye izidakamizwa noma ukwelashwa kufanele kuthathe indawo ye-Ruxolitinib uma ungayifanele.
Isikhathi sokuthumela: Apr-25-2022