I-Crisaborole iyilungu lesigaba se-benzoxaboroles okuyi-5-hydroxy-1,3-dihydro-2,1-benzoxaborole lapho i-phenolici-hydrogenithathelwe indawo iqembu le-4-cyanophenyl. I-phosphodiesterase 4 inhibitor esetshenziselwa ukwelapha i-atopic dermatitis ethambile kuya kwemaphakathi ezinganeni nakubantu abadala. Inendima njenge-phosphodiesterase IV inhibitor, ii-antipsoriatickanye nomuthi ongeyona i-steroidal eqeda ukuvuvukala. I-benzoxaborole, i-ether enamakha kanye ne-nitrile.

I-Crisaborole inovelioxaborolekugunyazwe i-FDA ngomhla ka-Disemba 14, 2016 njenge-Eucrisa, ukwelashwa kwe-topical kwe-atopic dermatitis ethambile kuya kwemaphakathi. Le ejenti engeyona eye-steroidal iyasebenza ekuthuthukiseni ukushuba kwesifo, ukunciphisa ingozi yokutheleleka kanye nokunciphisa izimpawu nezimpawu ezigulini ezineminyaka engu-2 ubudala nangaphezulu. Inciphisa ukuvuvukala kwendawo esikhumbeni futhi ivimbele ukukhushulwa okuqhubekayo kwesifo ngephrofayili enhle yokuphepha. Isakhiwo sawo siqukethe aibhoronii-athomu, eyenza isikhumba singene futhi sibophe esikhungweni se-bimetal se-phosphodiesterase 4 enzyme. Okwamanje isathuthukiswa njengokwelashwa kwe-psoriasis ngama-topical.

I-Crisaborole iyi-Phosphodiesterase 4 Inhibitor. Indlela yokusebenza ye-crisaborole injenge-Phosphodiesterase 4 Inhibitor.