I-Crisaborole iyilungu lesigaba se-benzoxaboroles okuyi-5-hydroxy-1,3-dihydro-2,1-benzoxaborole lapho i-phenolici-hydrogenithathelwe indawo yiqembu le-4-cyanophenyl.I-phosphodiesterase 4 inhibitor esetshenziselwa ukwelapha i-atopic dermatitis ethambile kuya kwemaphakathi ezinganeni nakubantu abadala.Inendima njenge-phosphodiesterase IV inhibitor, ii-antipsoriatickanye nomuthi ongeyona i-steroidal eqeda ukuvuvukala.I-benzoxaborole, i-ether enamakha kanye ne-nitrile.

I-Crisaborole inovelii-oxaborolekugunyazwe yi-FDA ngomhla ka-Disemba 14, 2016 njenge-Eucrisa, ukwelashwa kwe-atopic okuthambile kuya kwemaphakathi.Le ejenti engeyona eye-steroidal iyasebenza ekuthuthukiseni ukuqina kwesifo, ukunciphisa ingozi yokutheleleka kanye nokunciphisa izimpawu nezimpawu ezigulini ezineminyaka engu-2 ubudala nangaphezulu.Inciphisa ukuvuvukala kwendawo esikhumbeni futhi ivimbele ukukhushulwa okuqhubekayo kwesifo ngephrofayili enhle yokuphepha.Isakhiwo sawo siqukethe aibhoronii-athomu, eyenza isikhumba singene futhi sibophe esikhungweni se-bimetal se-enzyme phosphodiesterase 4.Njengamanje isathuthukiswa njengokwelashwa kwe-psoriasis ngama-topical.

I-Crisaborole iyi-Phosphodiesterase 4 Inhibitor.Indlela yokusebenza ye-crisaborole injenge-Phosphodiesterase 4 Inhibitor.