I-Chlorothiazide
Ingemuva
I-Chlorothiazide iyi-inhibitor ye-carbonic anhydrase futhi inamandla amancane kune-acetazolamide. Lesi sakhi siboniswe ukuthi sivimba ukumuncwa kabusha kwe-sodium ne-chloride ion.
Incazelo
I-Chlorothiazide iyi-diuretic ne-antihypertensive. (IC50=3.8 mM) Okuqondisiwe: Okunye I-Chlorothiazide sodium (Diuril) iwumuthi wokukhipha isisu osetshenziswa ngaphakathi kwelungiselelo lasesibhedlela noma ukuze uyisebenzisele wena ukulawula uketshezi oluningi oluhambisana nokuqunjelwa kwenhliziyo. Ibuye isetshenziswe njenge-antihypertensive. Okuvame ukuthathwa njengephilisi, ngokuvamile liphuzwa ngomlomo kanye noma kabili ngosuku. Esimweni se-ICU, i-chlorothiazide inikezwa ukuhlanza isiguli ngaphezu kwe-furosemide (Lasix). Isebenza ngendlela ehlukile kune-furosemide, futhi imuncwe ngokungenisa njengokumiswa kabusha okulawulwa ngeshubhu le-nasogastric (NG tube), le mithi emibili inamandla enye kwenye.
Ukuhlolwa Komtholampilo
| Inombolo ye-NCT | Umxhasi | Isimo | Usuku okuqalwa ngalo | Isigaba |
| I-NCT03574857 | Inyuvesi yaseVirginia | Ukwehluleka Kwenhliziyo|Ukwehluleka Kwenhliziyo Ngengxenyana Eyehlisiwe Yokukhipha|Ukwehluleka Kwenhliziyo Kushubile|Izifo Zenhliziyo | Juni 2018 | Isigaba 4 |
| I-NCT02546583 | Yale University|National Heart, Lung, and Blood Institute (NHLBI) | Ukuhluleka Kwenhliziyo | Agasti 2015 | Akufaneleki |
| I-NCT02606253 | I-Vanderbilt University|Vanderbilt University Medical Center | Ukuhluleka Kwenhliziyo | February 2016 | Isigaba 4 |
| I-NCT00004360 | Isikhungo Sikazwelonke Sezinsiza Zocwaningo (NCRR)|Northwestern University|Office of Rare Diseases (ORD) | Isifo sikashukela i-Insipidus, i-Nephrogenic | Septhemba 1995 |
|
| I-NCT00000484 | National Heart, Lung, and Blood Institute (NHLBI) | Izifo Zenhliziyo | Izifo Zenhliziyo | Umfutho Wegazi | Izifo Zemithambo | Ephreli 1966 | Isigaba 3 |
Isakhiwo samakhemikhali
Isiphakamiso18Amaphrojekthi Wokuhlola Ukuvumelana Kwekhwalithi asegunyaziwe4, futhi6amaphrojekthi angaphansi kokugunyazwa.
Uhlelo lokuphatha ikhwalithi yamazwe ngamazwe oluthuthukile lwenze isisekelo esiqinile sokuthengisa.
Ukugadwa kwekhwalithi kusebenza kuwo wonke umjikelezo wempilo womkhiqizo ukuze kuqinisekiswe ikhwalithi nomphumela wokwelapha.
Ithimba Lezindaba Zokulawula Ochwepheshe lisekela izimfuno zekhwalithi ngesikhathi sokufaka isicelo nokubhaliswa.
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