Ingemuva

I-Canagliflozin inoveli, inamandla, futhi ikhetha kakhulu i-sodium glucose co-transporter (SGLT) 2 inhibitor [1]. Kufakazelwe ukuthi i-Canagliflozin ingakhuphula ukuphuma kwe-glucose yomchamo ngokunciphisa umkhawulo we-glucose ezinso kanye nokunciphisa ukumuncwa kabusha kwe-glucose ehlungiwe.

I-Canagliflozin iboniswe ukuthi ivimbela ukungena kwe-Na+-mediated 14C-AMG ku-CHO-hSGLT2, CHO-rat SGLT2 kanye ne-CHO-mouse SGLT2 ngamavelu e-IC50 angu-4.4, 3.7 kanye no-2.0 nM, ngokulandelana [1].

I-Canagliflozin kubikwe ukuthi yehlisa amazinga eglucose yegazi (BG) ngokuncika kumthamo kuwo womabili Amagundane e-db/db kanye ne-Zucker Diabetic Fatty (ZDF) Rats. Ukwengeza, i-canagliflozin ibonakale yehlisa isilinganiso sokushintshana kokuphefumula, nesisindo somzimba kumagundane e-DIO namagundane e-ZDF [1].

I-Canagliflozin ingathathwa ngomlomo [1].

Izithenjwa:
[1] U-Liang Y1, Arakawa K, Ueta K, Matsushita Y, Kuriyama C Martin T, Du F, Liu Y, Xu J, Conway B, Conway J, Polidori D, Ways K, Demarest K. Umphumela we-canagliflozin embundwini wezinso ye-glucose, i-glycemia, nesisindo somzimba kumamodeli ezilwane ezijwayelekile nezinesifo sikashukela. I-PLoS One. 2012;7(2):e30555
[2] Sarnoski-Brocavich S, Hilas O. Canagliflozin (Invokana), I-ejenti Yomlomo Yenoveli Yohlobo Lwesifo Sikashukela. P T. 2013 Nov;38(11):656-66

Ukucaphuna Komkhiqizo

Bahia Abbas Moussa, Marianne Alphonse Mahrouse, et al. "Izindlela zokuxazulula ezihlukene zokuphatha i-spectra egqagqene: Isicelo sokunqunywa kwezidakamizwa ze-hypoglycemic ezinoveli ezakhiwe ngokuhlanganyela efomini lazo lemithamo ehlanganisiwe yemithi." I-Spectrochimica Acta Ingxenye A: I-Molecular and Biomolecular Spectroscopy Itholakala ku-inthanethi zingama-20 kuJuni 2018.

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