I-Vericiguat iyi-apyrazolopyridineleyo5-fluoro-1H-pyrazolo[3,4-b]pyridinelapho i-amino hydrogen esendaweni 1 ithathelwe indawo yiqembu le-2-fluorobenzyl kanyei-hydrogenendaweni yesi-3 ifakwe i-4,6-diamino-5--[(methoxycarbonyl)amino]pyrimidin-2-yl iqembu.Iyancibilikai-guanylatei-cyclase stimulator esetshenziselwa ukwelapha ukwehluleka kwenhliziyo okungapheli.Inendima njenge-solublei-guanylatei-cyclase activator, i-agent ye-vasodilator kanye ne-ejenti ye-antihypertensive.Kuyi-i-aminopyrimidine, apyrazolopyridine, i-carbamate ester kanye nenhlanganisela ye-organofluorine.

I-Vericiguat ingaphansi kophenyo esivivinyweni somtholampilo i-NCT02861534 (Ucwaningo Lwe-Vericiguat Kubahlanganyeli Abanenhliziyo Ehluleka Ngengxenye Eyehlisiwe Yokukhipha (HFrEF) (MK-1242-001)).

I-Vericiguat iyi-SolubleI-GuanylateI-Cyclase Stimulator.Indlela yokusebenza ye-vericiguat injenge-aI-GuanylateI-Cyclase Stimulator.

I-Vericiguat umuthi osetshenziselwa ukuphatha nokwelapha ukwehluleka kwenhliziyo nge-fraction encishisiwe ye-ejection (HFrEF).Iwusizo ekuhlulekeni kwenhliziyo okuba kubi kakhulu, ukuhluleka kwenhliziyo okusanda kuncishiswa.I-Vericiguat ayikwendisi isikhathi sokuphila kodwa ivimbela ukulashwa kabusha.Lo msebenzi uveza izinkomba, indlela yokwenza, umthamo, kanye nendlela yokuphatha ithimba labachwepheshe, imiphumela emibi, ukuphikisana, nokuhlola okuningana ukusekela ubufakazi bokuthi umuthi uwusizo ku-HFrEF.