I-Relugolix isetshenziselwa ukwelapha umdlavuza wendlala yesinye emadodeni.
Amagama Brand: Orgovyx
Isigaba Sezidakamizwa: I-Antineoplastic - LHRH (GnRH) Ama-Antagonist Pituitary Suppressants
Ukutholakala: Incwadi kadokotela iyadingeka
Ukukhulelwa: Xhumana nodokotela wakho.Lo muthi ungase ube yingozi enganeni engakazalwa.
Ukuncelisa: Bonana nodokotela ngaphambi kokusebenzisa

I-Relugolix iyi-antagonist etholakala ngomlomo, engeyona i-peptide gonadotropin-releasing hormone (GnRH noma i-luteinizing hormone-releasing hormone (LHRH)) ), enekhono lomsebenzi we-antineoplastic.I-Relugolix ngokuncintisana ibophezela futhi ivimbe isamukeli se-GnRH ku-anterior pituitary gland, okuvimbela kokubili i-GnRH ukubopha isamukeli se-GnRH futhi ivimbele ukukhishwa nokukhululwa kwakho kokubili i-hormone ye-luteinizing (LH) kanye ne-follicle stimulating hormone (FSH).Kwabesilisa, ukuvinjelwa kokukhiqizwa kwe-LH kuvimbela ukukhululwa kwe-testosterone kumaseli e-Leydig kumasende.Njengoba i-testosterone idingeka ukuze kuthuthukiswe ukukhula kwe-prostate, ukunciphisa amazinga e-testosterone kungase kuvimbele ukwanda kwamangqamuzana omdlavuza we-prostate oncike ku-hormone.

I-Relugolix iyi-gonadotropin-releasing hormone (GnRH) receptor antagonist esetshenziswa ekwelapheni izimo ezimbalwa zokusabela kwehomoni.Yamukelwa okokuqala eJapan ngo-2019, ngaphansi kwegama lomkhiqizo i-Relumina, yokwelashwa okuyizimpawu kwe-uterine fibroids, futhi muva nje yi-United States' FDA ngo-2020, ngaphansi kwegama lomkhiqizo i-Orgovyx, yokwelapha umdlavuza wendlala yesinye.I-Relugolix nayo ifundwe ekwelapheni okuyizimpawu ze-endometriosis.I-Relugolix ingeyokuqala (futhi okwamanje kuphela) ephikiswa ngomlomo ye-GnRH receptor egunyazwe ukwelashwa komdlavuza wendlala yesinye - izindlela zokwelapha ezifanayo njengokuthi [i-degarelix] zidinga ukuphathwa ngaphansi kwesikhumba - ngakho-ke inikeza inketho yokwelapha engasindi kakhulu ezigulini ezingase zidinge ukuvakashelwa emtholampilo. ukuze kuphathwe ochwepheshe bezempilo.Ngaphezu kokusebenziseka kalula kwayo, i-relugolix yaboniswa ukuthi iphakeme ekucindezelekeni kwamazinga e-testosterone uma iqhathaniswa ne-[leuprolide], enye indlela yokwelapha yokuncisha i-androgen esetshenziswa ekwelapheni umdlavuza wendlala yesinye.

I-Relugolix iyi-Gonadotropin Ekhulula I-Hormone Receptor Antagonist.Indlela yokusebenza ye-relugolix injenge-Gonadotropin Releasing Hormone Receptor Antagonist, ne-Cytochrome P450 3A Inducer, ne-Cytochrome P450 2B6 Inducer, kanye ne-Breast Cancer Resistance Protein Inhibitor, ne-P-Glycoprotein Inhibitor.Umphumela we-physiologic we-relugolix ungowe-Decreased GnRH Secretion.

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