Amaphilisi e-Atorvastatin calcium namaphilisi e-calcium e-rosuvastatin womabili amaphilisi ehlisa i-lipid-lipid, futhi womabili awemithi yama-statin enamandla. Umehluko othize umi kanje:

1. Ngokombono we-pharmacodynamics, uma umthamo ufana, umphumela wokwehlisa i-lipid we-rosuvastatin unamandla kunalowo we-atorvastatin, kodwa kumthamo ojwayelekile onconywe emtholampilo, umphumela wokwehlisa i-lipid wale mithi yomibili ngokuyisisekelo uyafana. ;

2. Ngokuphathelene nemithi esekelwe ebufakazini, njengoba i-atorvastatin ibilokhu isemakethe ngaphambili, kunobufakazi obuningi be-atorvastatin ezifweni zenhliziyo ne-cerebrovascular kune-rosuvastatin; 3. Mayelana ne-metabolism yezidakamizwa, kunomehluko othile phakathi kwalokhu kokubili. I-Atorvastatin igaywa kakhulu yisibindi, kuyilapho ingxenye encane kuphela ye-rosuvastatin igaywa yisibindi. Ngakho-ke, i-atorvastatin ijwayele ukusebenzisana nezidakamizwa okubangelwa ama-enzyme ezidakamizwa zesibindi;

4. I-Atorvastatin ingaba nokusabela okubi kwesibindi okuningi kune-rosuvastatin. Uma kuqhathaniswa ne-atorvastatin, imiphumela emibi ye-rosuvastatin ingase ibe maningi amathuba okuba yenzeke ezinso. Ngamafuphi, i-atorvastatin ne-rosuvastatin zombili izidakamizwa ezinamandla zokwehlisa i-lipid-lipid, futhi kungase kube nomehluko ekusetshenzisweni kwezidakamizwa, ukusebenzisana kwezidakamizwa, kanye nokusabela okungekuhle.