I-Ruxolitinib, eyaziwa nangokuthi i-ruxolitinib e-China, ingenye "yemithi emisha" ebhalwe kabanzi eziqondisweni zomtholampilo zokwelashwa kwezifo ze-hematological eminyakeni yamuva, futhi ibonise ukusebenza okuthembisayo kwezifo ze-myeloproliferative.
Isidakamizwa esihlosiwe i-Jakavi ruxolitinib singavimbela ngempumelelo ukusebenza kwesiteshi sonke se-JAK-STAT futhi sinciphise isignali ethuthukiswe ngendlela engavamile yesiteshi, ngaleyo ndlela izuze ukusebenza kahle.Ingase futhi isetshenziselwe ukwelapha izifo ezihlukahlukene, kanye nokungajwayelekile kwendawo ye-JAK1.
I-Ruxolitinibi-kinase inhibitor ekhonjiswe ekwelapheni iziguli ezine-myelofibrosis ephakathi noma engozini enkulu, kuhlanganise ne-myelofibrosis eyinhloko, i-post-geniculocytosis myelofibrosis, kanye ne-post-primary thrombocythemia myelofibrosis.
Ucwaningo olufanayo lomtholampilo (n=219) iziguli ezingahleliwe ezine-MF emaphakathi-engozini-2 noma eyingozi enkulu, iziguli ezine-MF ngemva kwe-erythroblastosis yangempela, noma iziguli ezine-MF ngemva kwe-thrombocytosis eyinhloko emaqenjini amabili, eyodwa ethola i-ruxolitinib yomlomo 15 kuya ku-20 mgbid (n=146) kanti omunye uthola umuthi olawula kahle (n=73).Iziphetho eziyinhloko nezibalulekile zesibili zocwaningo kwakuyiphesenti leziguli ezine-≥35% yokunciphisa umthamo we-spleen (ihlolwe yi-imaging resonance magnetic noma i-computed tomography) emavikini angu-48 no-24, ngokulandelana.Imiphumela ibonise ukuthi iphesenti yeziguli ezine-35% yokunciphisa umthamo we-spleen kusukela ekuqaleni kweviki 24 yayingu-31.9% eqenjini lokwelapha uma kuqhathaniswa ne-0% eqenjini lokulawula (P <0.0001);kanye nephesenti yeziguli ezine-35% yokunciphisa umthamo we-spleen kusukela ekuqaleni kweviki 48 yayingu-28.5% eqenjini lokwelapha uma kuqhathaniswa ne-0% eqenjini lokulawula (P <0.0001).Ngaphezu kwalokho, i-ruxolitinib iphinde yehlisa izimpawu eziphelele futhi yathuthukisa kakhulu izinga lokuphila ezigulini.Ngokusekelwe emiphumeleni yalezi zivivinyo ezimbili zomtholampilo,i-ruxolitinibyaba umuthi wokuqala ogunyazwe yi-US FDA yokwelapha iziguli ezine-MF.