Incazelo

IHydrochlorothiazide (HCTZ), umuthi osebenza ngomlomo wesigaba se-thiazide, inqanda ukuguqula i-TGF-β/Indlela yokusayina esmad.IHydrochlorothiazide inemiphumela eqondile yokuphumuza imithambo ngokuvula isiteshi se-calcium-activated potassium (KCA).IHydrochlorothiazide ithuthukisa ukusebenza kwenhliziyo, yehlisa i-fibrosis futhi inomphumela we-antihypertensive.

Ingemuva

IHydrochlorothiazide iyisidakamizwa se-diuretic sesigaba se-thiazide.

Ku-Vitro

IHydrochlorothiazide ingeyesigaba se-thiazide se-diuretics.Yehlisa umthamo wegazi ngokusebenza ezinso ukunciphisa ukumuncwa kabusha kwe-sodium (Na) ku-distal convoluted tubule.Indawo enkulu yesenzo ku-nephron ibonakala ku-electroneutral Na+-Cl co-transporter ngokuqhudelana nendawo ye-chloride kumthuthi.Ngokonakalisa ezokuthutha ze-Na ku-distal convoluted tubule, i-hydrochlorothiazide idala i-natriuresis kanye nokulahlekelwa kwamanzi okuhambisanayo.Ama-Thiazide akhuphula ukumuncwa kabusha kwe-calcium kule ngxenye ngendlela engahlobene nokuthuthwa kwe-sodium.Ukwengeza, ngezinye izindlela, i-Hydrochlorothiazide kukholakala ukuthi yehlisa ukumelana ne-peripheral vascular.

I-Hydrochlorothiazide (i-HCTZ; i-oral bygavage; 12.5 mg/kg/d; amaviki angu-8) ithuthukise ukusebenza kwenhliziyo, yanciphisa inhliziyo ye-interstitial fibrosis kanye nengxenye yevolumu ye-collagen, yehla ukubonakaliswa kwe-AT1, TGF-β kanye ne-Smad2 ezicutshini zenhliziyo kumagundane abesilisa abadala ase-Sprague Dawley.Ngaphezu kwalokho, i-hydrochlorothiazide yehlisa i-plasma angiotensin II namazinga e-aldosterone.Ngaphezu kwalokho, i-hydrochlorothiazide ivimbela i-angiotensin II-induced TGF-.β1 kanye ne-Smad2 protein expression in the neonatal rat ventricular fibroblasts.

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