Ingemuva

I-Agomelatine i-agonist yama-melatonin receptors kanye nomphikisi we-serotonin 5-HT2C receptor enamanani e-Ki angu-0.062nM kanye ne-0.268nM kanye nevelu ye-IC50 ye-0.27μM, ngokulandelanayo ku-MT1, MT2 kanye ne-5-HT2C [1].

I-Agomelatine iyi-antidepressant eyingqayizivele futhi yenzelwe ukwelashwa kwe-depressive disorder enkulu (MDD). I-Agomelatine ikhetha uma iqhathaniswa ne-5-HT2C. Ibonisa ukuhambisana okuphansi kumuntu owenziwe yi-5-HT2A kanye ne-5-HT1A. Kuma-melatonin receptors, i-agomelatine ikhombisa ukuhlobana okufanayo ne-MT1 yomuntu eyenziwe ngamakhanda kanye ne-MT2 enamanani e-Ki angu-0.09nM no-0.263nM, ngokulandelana. Ezifundweni ze-vivo, i-agomelatine ibangela ukwanda kwamazinga e-dopamine ne-noradrenaline ngokuvimbela okokufaka okungavimbeli kwe-5-HT2C. Ngaphezu kwalokho, ukuphathwa kwe-agomelatine kuphikisa ukwehla okubangelwa ingcindezi ekusetshenzisweni kwe-sucrose kumodeli yegundane yokudangala. Ngaphandle kwalokho, i-agomelatine isebenzisa ukusebenza ngempumelelo kokukhathazeka ngendlela yegundane yokukhathazeka [1].

Izithenjwa:
[1] Zupancic M, Guilleminault C. Agomelatine. Izidakamizwa ze-CNS, 2006, 20(12): 981-992.

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