Ingemuva

I-Agomelatine i-agonist yama-melatonin receptors kanye nomphikisi we-serotonin 5-HT2C receptor enamanani e-Ki angu-0.062nM kanye ne-0.268nM kanye nevelu ye-IC50 ye-0.27μM, ngokulandelanayo ku-MT1, MT2 kanye ne-5-HT2C [1].

I-Agomelatine iyi-antidepressant eyingqayizivele futhi yenzelwe ukwelashwa kwe-depressive disorder enkulu (MDD).I-Agomelatine ikhetha uma iqhathaniswa ne-5-HT2C.Ibonisa ukuhambisana okuphansi kumuntu owenziwe yi-5-HT2A kanye ne-5-HT1A.Kuma-melatonin receptors, i-agomelatine ikhombisa ukuhlobana okufanayo kwe-MT1 yomuntu ekhiqizwe kanye ne-MT2 enamanani e-Ki angu-0.09nM no-0.263nM, ngokulandelana.Ezifundweni ze-vivo, i-agomelatine ibangela ukwanda kwamazinga e-dopamine kanye ne-noradrenaline ngokuvimbela okokufaka okungavimbeli kwe-5-HT2C.Ngaphezu kwalokho, ukuphathwa kwe-agomelatine kuphikisa ukwehla okubangelwa ingcindezi ekusetshenzisweni kwe-sucrose kumodeli yegundane yokudangala.Ngaphandle kwalokho, i-agomelatine isebenzisa ukusebenza ngempumelelo kokukhathazeka emodeli yegundane yokukhathazeka [1].

Izithenjwa:
[1] Zupancic M, Guilleminault C. Agomelatine.Izidakamizwa ze-CNS, 2006, 20(12): 981-992.

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